The main difference in side effects of commonly prescribed antihistamines

For our HCP’s, a helpful summary to cut out and keep!  Available as syrups, tablets, nasal sprays, eye drops, and intravenous formulations antihistamines are the most common drug prescribed in patients with allergic conditions. Although all antihistamines oppose the action of histamine, they differ quite significantly in their chemical structure, leading to a huge difference in especially their duration of action, side effect profile and the ability to interact with other drugs taken simultaneously. Antihistamines can conveniently be subdivided into two groups: older (first generation-) antihistamines and newer (second generation-) antihistamines.

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